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Frequently Asked Questions

What are neuroplastic pain and symptoms?

  • Neuroplastic symptoms can be defined as pain or other symptoms caused and amplified by brain and nervous system processes and are not due to disease or structural damage in the body1. What occurs is that the brain and nervous system become sensitized due to a person being stuck in a state of dysregulation, and as a result, the brain produces pain or other symptoms2. The factor that drives the symptoms to be created, amplified, and maintained is when our brain and nervous system are in a prolonged state of danger. It is important to note that neuroplastic pain or other symptoms are very real and occur in the brain3. Our clinic specializes in helping clients effectively treat symptoms that are fully or partially neuroplastic.

What causes neuroplastic pain and symptoms?

  • Neuroplastic pain and symptoms occur when the brain and nervous system are sensitized. The following factors can cause sensitization: 2,3,4,5,6,7,8,9,10

    • Initial Injury or infection that has since healed

    • Belief that the body is permanently damaged or flawed

    • Responding to pain/symptoms with worry, frustration, grief, or despair

    • Anxiety or depression

    • Unprocessed trauma

    • Nervous system dysregulation

    • High-stress habits like perfectionism, people-pleasing, excessive control, self-criticism, and/or obsessive thinking

    • Avoiding emotions

    • Social and environmental factors that create a sense of danger

Which conditions can be fully or partially neuroplastic and effectively treated with our approach? 1,2

    • Fibromyalgia

    • Chronic neck and back pain

    • Headaches and migraines

    • Chronic Fatigue Syndrome (CFS)

    • Long COVID

    • Abdominal and pelvic pain

    • Irritable bladder

    • Irritable bowel

    • Tinnitus

    • Vestibular concerns and dizziness

    • Complex Regional Pain Syndrome (CRPS)

    • Postural Orthostatic Tachycardia Syndrome (POTS)

    • Environmental and chemical sensitivities

    *It is always important to meet with a physician in order for structural damage and disease to be ruled out.

How are neuroplastic pain and symptoms assessed in therapy?

  • For many clients, symptoms appear or worsen around the time of a particularly stressful or emotional event. Examples could include a wedding, divorce, new baby, family illness or death, beginning university, financial difficulties, career stressors, etc. It’s not about the event itself, but the level of nervous system dysregulation experienced; even events that seem small can trigger neuroplastic pain2,11.

  • Pain/symptoms often occur without a clear injury2,11.

    “I woke up with the pain/symptoms” or “It just got worse over time”

    If you are injured, pain/symptoms are appropriate at first. However, most injuries heal within a few weeks to a few months. Your body evolved to heal! If the symptoms emerge without injury, or persist long past the typical time of healing, it could be a sign it’s neuroplastic.

  • Problems in relationships, difficulties at work, and systemic stressors like loneliness, poverty, racism, gendered oppression, or sexuality-based oppression can cause increases in pain/symptoms. If your pain/symptoms worsen when stress and emotional difficulty are high, and reduce when you feel safe and calm, it’s a sign they are neuroplastic2,11.

  • Stimuli and activities like weather, smells, foods, workplaces, noises, or lighting can become unexpected triggers for pain/symptoms. If your brain has associated certain stimuli with danger, then to protect you from the danger, it will generate neuroplastic pain/symptoms - and this reinforces the sense that the stimuli is indeed dangerous. If you are noticing triggers you wouldn’t expect to cause physical pain/symptoms, it could mean your symptoms are neuroplastic2.

  • Structural injuries, damage, and diseases in the body typically behave quite consistently. In contrast, with neuroplastic pain/symptoms, your symptoms may change day-to-day. Sometimes it’s quite confusing, as there’s no clear sense of why it feels better or worse. Quicker, confusing, or more spontaneous shifts in symptom location and intensity suggest they are neuroplastic2,11.

  • The spread of symptoms often causes fear, confusion, and frustration, but on the bright side, it can suggest your pain/symptom is neuroplastic and treatable with a mind-body approach. Structural pain/symptoms are typically localized to injury sites or structural problems in the body. If your symptoms have migrated around the body over time, or become symmetrical, this suggests they may be neuroplastic rather than structural2,11.

  • If there are multiple symptoms occurring in your body that are difficult to explain, sensitization in the brain and nervous system may be the common explanation. While multiple chronic pain/symptoms could be coming from injuries or systemic disorders, when medical assessment finds no structural cause or cure, it suggests a sensitized brain is the central cause2. This can look like:

    • Having 3 or more chronic pains/symptoms

    • A history of serial symptoms (one after another)

  • Sometimes we engage in a physical activity or tasks, and it feels okay in the moment, only for pain/symptoms to flare up later. Structural pain/symptoms don’t typically behave this way. Injurious movements/stimuli should cause symptoms while they are happening. Pain/symptoms emerging after exposure to a movement, activity, or stimuli are often neuroplastic, not structural2.

    • Example: I go for a bike ride and experience higher pain the next day

    • Example: I feel dizzy after a busy day

  • If you’ve had various scans, tests and assessments, and physicians/specialists are unable to find a structural problem to accurately explain your symptoms, it can suggest they are neuroplastic. Furthermore, many of our clients have been given a structural diagnosis, yet their symptoms are neuroplastic.

    If the diagnosis just isn’t making sense, or you’ve tried many different physical treatments and medications with little success, it can suggest that you are trying to heal problems in the wrong place.

    We always recommend an extensive physical assessment from a skilled medical provider. However, if structural problems can’t be accurately diagnosed and treated, it may be time to shift your treatment focus from the body to the brain and nervous system2,11.

  • Pain and symptoms are designed to protect us. So is entering a nervous system state of fight, flight, fawn, or freeze/shutdown. Bodies are designed to move in and out of danger, but becoming stuck in states of dysregulation can sensitize and trigger neuroplastic pain.

  • Experiences of neglect, trauma, bullying, and accidents in childhood can lead to feeling unsafe in your body and relationships. Research shows strong connections between childhood adversity and developing chronic pain/symptoms. A brain that feels chronically unsafe is more at risk of developing neuroplastic pain and symptoms2,12,13,14,15.

  • Survivors of physical, sexual, and psychological trauma are much more likely to develop chronic pain/symptoms. Adults are 2.7 times more likely to have chronic widespread pain, fibromyalgia, chronic fatigue, or IBS, following trauma in childhood or adulthood4. Furthermore, higher rates of dizziness/vestibular concerns were found with veterans who have PTSD compared to veterans who didn’t have PTSD12.

  • While not always considered, the experiences and life impacts of chronic pain/symptoms can also cause trauma. Sensitization trauma is prolonged dysregulation caused by the onset and progression of chronic pain/symptoms. Medical trauma is prolonged dysregulation caused by medical procedures, experiences, or treatments16,17. Trauma that is not processed and healed can lead to the development and amplification of neuroplastic pain/symptoms. 

  • Chronically dangerous or oppressive social factors that cause individuals to feel unsafe in their world and relationships can cause pain/symptoms. Studies show social factors such as poverty, abusive relationships, racism, bullying, and being part of the LGBTQ+ community can significantly increase the likelihood of experiencing chronic pain and symptoms7,9,13,18. Pain/symptoms can be viewed as meaningful messages; the brain is signalling danger in an attempt to protect.

  • Through attempts to understand and fix the problem, individuals with chronic pain/symptoms often develop pathological beliefs about their bodies. Through interactions with various health professionals, forums, and online research, many concerning physical conditions may be learned. While structural diagnosis is meant to help, when the symptom is actually neuroplastic, pathological labels can create increased fear, confusion, frustration, and despair. Viewing the body as broken, abnormal, or unable to heal increases fear, changes behaviour, and amplifies neuroplastic pain/symptoms.

    *Please note it is important to meet with a medical professional to ensure neuroplastic symptoms are assessed properly. Please do not use these criteria to diagnose yourself. We request all of our clients first see a physician to ensure medical conditions with a clear physical cause have been ruled out. For a formal diagnosis of neuroplastic symptoms, we refer our clients to physicians specialized in it.

What is the treatment for neuroplastic pain and symptoms?

  • Our approach utilizes tools and education from Pain Reprocessing Therapy, Emotional Awareness and Expression Therapy, Somatic Experiencing, Polyvagal Theory, and other trauma-focused therapies, to treat chronic pain and symptoms. We use a detailed and holistic approach focused on 5 main areas:

    1. Changing thoughts and beliefs about the body

    2. Brain retraining & graded exposure

    3. Processing emotions and regulating the nervous system

    4. Treating trauma

    5. Increasing social safety

    Our approach is one of the most comprehensive brain-based approaches to treating chronic pain and symptoms. We are the largest and most experienced private clinic in Canada, solely focused on providing a psychological approach to treating chronic symptoms.

How long does it take to treat neuroplastic pain and symptoms?

  • Treatment length for neuroplastic pain and symptoms differs for each person. The following factors can influence how long it takes for a person to start seeing pain or symptom reduction using our treatment:

    • Duration and severity of chronic symptoms

    • Mental health concerns

    • Trauma history

    • Severity of nervous system dysregulation

    • Level of Social danger or safety

    It is important to understand that everyone’s brain and nervous system is unique, so treatment duration can vary greatly. For many people, healing takes time, and this is normal.


  1. Clarke, D. D., & Schubiner, H. (2019). Introductions. In D. Clarke, H. Schubiner, M. Clarke-Smith, & A. Abbass (Eds.), Psychophysiologic disorders: Trauma informed, interprofessioal diagnosis and treatment (pp. 5-25). Psychophysiologic Disorders Association.

  2. Pain Reprocessing Therapy Center (2021). Pain reprocessing therapy training.

  3. Kirwilliam, S. S., & Derbyshire, S. W. G. (2008). Increased bias to report heat or pain following emotional priming of pain-related fear. Pain 137(1), 60-65.

  4. Barrett, L., & Simmons, W. K. (2015). Interoceptive predictions in the brain. Nature Reviews Neuroscience 16, 419-429.

  5. Kross, E., Berman, M. G., Mischel, W., Smith, E. E., Wager, T. D. (2011). Social rejection shares somatosensory representations with physical pain. Proceedings of the National Academy of Sciences of the USA 108, 6270-6275.

  6. Dana, D. (2018). The polyvagal theory in therapy: Engaging the rhythm of regulation. WW Norton & Co. 

  7. Mills, S. E. E., Nicolson, K. P., & Smith, B. H. (2019). Chronic pain: a review of its epidemiology and associated factors in population-based studies. British journal of anaesthesia123(2), e273–e283. https://doi.org/10.1016/j.bja.2019.03.023

  8. Schubiner, H., Jackson, B., Molina, K. M., Sturgeon, J. A., Sealy-Jefferson, S., Lumley, M. A., Jolly, J., & Trost, Z. (2023). Racism as a Source of Pain. Journal of general internal medicine38(7), 1729–1734. https://doi.org/10.1007/s11606-022-08015-0

  9. Zajacova, A., Grol-Prokopczyk, H., Liu, H., Reczek, R., & Nahin, R. L. (2023). Chronic pain among U.S. sexual minority adults who identify as gay, lesbian, bisexual, or "something else". Pain164(9), 1942–1953. https://doi.org/10.1097/j.pain.0000000000002891

  10. Anda, R. F., Felitti, V. J., Bremner, J. D., Walker, J. D., Whitfield, C., Perry, B. D., Dube, S. R., & Giles, W. H. (2006). The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology. European Archives of Psychiatry and Clinical Neuroscience 256, 174-186.

  11. Lumley, M. A., & Schubiner, H. (2019). Psychological Therapy for Centralized Pain: An Integrative Assessment and Treatment Model. Psychosomatic medicine, 81(2), 114–124. https://doi.org/10.1097/PSY.0000000000000654

  12. Afari, N., Ahumada, S. M., Wright, L. J., Mostoufi, S., Golnari, G., Reis, V., & Cuneo, J. G. (2014). Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis. Psychosomatic medicine, 76(1), 2–11. https://doi.org/10.1097/PSY.0000000000000010

  13. Green, C. R., FloweValencia, H., Rosenblum, L., & Tait, A. R. (2001). The role of childhood and adulthood abuse among women presenting for chronic pain. The Clinical Journal of Pain 17, 359-364.

  14. Stuart, S., & Noyes, R., Jr (1999). Attachment and interpersonal communication in somatization. Psychosomatics, 40(1), 34–43. https://doi.org/10.1016/S0033-3182(99)71269-7

  15. Nicolson, K. P., Mills, S. E. E., Senaratne, D. N. S., Colvin, L. A., & Smith, B. H. (2023). What is the association between childhood adversity and subsequent chronic pain in adulthood? A systematic review. BJA open, 6, 100139. https://doi.org/10.1016/j.bjao.2023.100139

  16. McBain, S., & Cordova, M. J. (2024). Medical traumatic stress: Integrating evidence-based clinical applications from health and trauma psychology. Journal of traumatic stress, 37(5), 761–767. https://doi.org/10.1002/jts.23075

  17.  Birk, J., Kronish, I., Chang, B., Cornelius, T., Abdalla, M., Schwartz, J., Duer-Hefele, J., Sullivan, A., & Edmondson, D. (2019). The Impact of Cardiac-induced Post-traumatic Stress Disorder Symptoms on Cardiovascular Outcomes: Design and Rationale of the Prospective Observational Reactions to Acute Care and Hospitalizations (ReACH) Study. Health psychology bulletin, 3, 10–20. https://doi.org/10.5334/hpb.16

  18. Wyatt R. (2013). Pain and ethnicity. The virtual mentor : VM, 15(5), 449–454. https://doi.org/10.1001/virtualmentor.2013.15.5.pfor1-1305